Caloric Restriction Could Mean a 20% Extension in Lifespan

Sinclair and several other prominent gerontologists are presently seeking human therapies based on the long-standing observation that lifelong restriction of caloric intake considerably extends both the healthy and total life span of nearly all species in which it has been tried, including rodents and dogs. Drugs that elicit the gene expression changes that result from caloric restriction might, these workers assert, extend human life span by something approaching the same proportion as seen ...

 The Unmentioned Trade-Offs in Life Extention

Now it is not that the cell biologists can’t point to experiments which seem to fit their views, as is common in natural science. (After all, the Earth’s Moon does indeed have a geocentric orbit.) Good colleagues of mine like Robert Reis are able to produce nematode worms that live ten times longer than their unmutated controls, if they use ingenious genetic and environmental manipulation. But nematodes have well-developed physiological machinery for sustaining states of metabolic arrest,...